Nexus Research
Real-world evidence research, designed to international methodology standards.
An independent methodology group based in Osaka, Japan. We partner with clinicians at tertiary hospitals in China to design, conduct, and report real-world evidence studies to international standards.
What We Do
We work as a unified team across the full study lifecycle — from clinical question to publication.
Design
Translating a clinical question into a methodologically defensible study. Causal frameworks, target trial emulation, protocols pre-registered on OSF before analysis begins.
Execute
Epidemiology, biostatistics, data engineering, modeling — an integrated team, not a chain of handoffs. Analysis code maintained openly on GitHub from day one.
Report
Studies reported to international standards (STROBE, RECORD-PE, STARD, TRIPOD+AI). Null and negative findings published.
Project Updates
Discover our active clinical methodology collaborations.
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How We Work
Our collaboration framework is designed against the failure modes of commercial clinical research.
Protocols pre-registered on OSF before data analysis begins.
Analysis code maintained openly on GitHub.
Authorship strictly per the ICMJE four-criteria standard. No gift authorship.
Engagement fees tied to methodological milestones, decoupled from publication outcome.
Methodology
Our methodology builds on the international real-world evidence community — causal inference and target trial emulation (Hernán, Robins), transparency and reproducibility frameworks (Shirley Wang, Schneeweiss), and regulatory science (ICH M14, FDA RWE guidance).
Partnership
We partner with attending- to chief-level physicians at tertiary hospitals in China, in specialties where treatment decisions are dense and outcomes are trackable.
We accept research collaborations that meet three conditions:
Clinical Uncertainty
The question reflects a real clinical uncertainty.
Methodological Tractability
The question is methodologically tractable given available data.
Clinical Significance
An answer would influence clinical practice.
Contact
If you have a clinical question grounded in real uncertainty and want it developed into a study that meets international standards, please write.
Email Address
Send your clinical questions or inquiry details directly to our lead.
Office Location
Room 401, 3-5, Nishinakajima 6-chome, Yodogawa-ku, Osaka-shi, Osaka, Japan
06-4965-3409
Methodology Digest
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